Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2.

  title={Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2.},
  author={G{\'a}bor Cs{\'a}nyi and Eugenia Cifuentes-Pagano and Imad Al Ghouleh and Daniel J Ranayhossaini and Loreto Ega{\~n}a and Lucia Rossetti Lopes and Heather M. Jackson and Eric E. Kelley and Patrick J Pagano},
  journal={Free radical biology & medicine},
  volume={51 6},
In recent years, reactive oxygen species (ROS) derived from the vascular isoforms of NADPH oxidase, Nox1, Nox2, and Nox4, have been implicated in many cardiovascular pathologies. As a result, the selective inhibition of these isoforms is an area of intense current investigation. In this study, we postulated that Nox2ds, a peptidic inhibitor that mimics a sequence in the cytosolic B-loop of Nox2, would inhibit ROS production by the Nox2-, but not the Nox1- and Nox4-oxidase systems. To test our… CONTINUE READING
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NAD(P)H oxidase inhibition attenuatesneuronalchronotropicactionsofangiotensinII.Circ.Res.96:659–666;2005

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