Nowadays which emergency contraception? Comparison between past and present: latest news in terms of clinical efficacy, side effects and contraindications

  title={Nowadays which emergency contraception? Comparison between past and present: latest news in terms of clinical efficacy, side effects and contraindications},
  author={S. Gizzo and T. Fanelli and S. di Gangi and C. Saccardi and T. S. Patrelli and A. Zambon and Anis Omar and D. D'Antona and G. Nardelli},
  journal={Gynecological Endocrinology},
  pages={758 - 763}
Despite many highly effective methods of contraception are available nowadays, many pregnancies are unintended. Emergency contraception (EC) is the use of drug or device after unprotected intercourse to prevent an unwanted pregnancy. It is a woman’s last chance to prevent unintended pregnancy. Nevertheless the confusion about mechanisms of action, side effects, clinical efficacy and controindications makes the intervention underused in every setting investigated. So far levonorgestrel (LNG) has… Expand
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Emergency contraception: potential role of ulipristal acetate
Evidence is provided that UPA, a new type of second-generation progesterone receptor modulator, represents a new evolutionary step in EC treatment and is in line with results from a series of clinical trials conducted recently which demonstrate that U PA seems to have higher EC efficacy compared to LNG. Expand
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An overview of the history of EC methods and the current availability of oral and intrauterine EC methods is provided and Clinicians should be aware of all available options in order to counsel women in need of EC appropriately. Expand
Interventions for emergency contraception.
Mifepristone middle dose (25-50 mg) was superior to other hormonal regimens and Levonorgestrel was more effective than the Yuzpe regimen in preventing pregnancy. Expand
Mechanism of action of emergency contraception.
Today, levonorgestrel (LNG) in a single dose of 1.5 mg taken within 120 h of an unprotected intercourse is the most widely used EC method worldwide and in an in vitro model, it was demonstrated that LNG did not interfere with blastocyst function or implantation. Expand
Ulipristal Acetate (ella): A Selective Progesterone Receptor Modulator For Emergency Contraception.
The female menstrual cycle comprises three distinct phases: follicular, ovulatory, and luteal; ulipristal acetate was developed to be a derivative of 19-norprogesterone, and the drug is used to prevent unintended pregnancy for up to five days after unprotected intercourse or contraceptive failure. Expand
How do levonorgestrel-only emergency contraceptive pills prevent pregnancy? Some considerations
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Review of the evidence suggests that LNG-ECPs cannot prevent implantation, and the Statement based on seven reference papers which considered a total of only 142 patients, divided into still different subgroups got quite different conclusions. Expand
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Ulipristal acetate provides women and health-care providers with an effective alternative for emergency contraception that can be used up to 5 days after unprotected sexual intercourse. Expand
Ulipristal Acetate Taken 48–120 Hours After Intercourse for Emergency Contraception
Ulipristal acetate is effective and well-tolerated for emergency contraception 48–120 hours after unprotected intercourse, and this results satisfy the protocol-defined statistical criteria for success. Expand