Novonestmycins A and B, two new 32-membered bioactive macrolides from Streptomyces phytohabitans HBERC-20821

  title={Novonestmycins A and B, two new 32-membered bioactive macrolides from Streptomyces phytohabitans HBERC-20821},
  author={Zhongyi Wan and Wei Fang and Liqiao Shi and Kaimei Wang and Yani Zhang and Zhigang Zhang and Zhaoyuan Wu and Ziwen Yang and Yucheng Gu},
  journal={The Journal of Antibiotics},
Two new 32-membered macrolide compounds, named Novonestmycins A (1) and B (2), were isolated from the soil strain Streptomyces phytohabitans HBERC-20821. Their structures were elucidated by using spectroscopic methods, including 1D, 2D-NMR and MS spectrometry. The two compounds showed strong activities against the phytophathogenic fungi Corynespora cassiicola, Rhizoctonia solani and Septoria nodorum, with MIC values of 0.78, 0.39 and 0.78 μg ml−1, respectively. In addition, the two compounds… Expand
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