Novobiocin-and Phorbol-12-myristate-13-acetate-induced Differentiation of Human Leukemia Cells Associated with a Reduction in Topoisomerase II Activity 1


Studies were conducted to determine the possible involvement of DNA topoisomerase II (Topo II) in the induction of differentiation in two human promyeloc)tic 111 (ill leukemia cell variants that are either sus ceptible or resistant to differentiation induced by phorbol-12-myristate13-acetate (I'M \). a protein kinase C activator. The acquisition of… (More)

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