Novobiocin Analogs as Potential Anticancer Agents.


BACKGROUND The aminocoumarin antibiotic, novobiocin, is a natural product that inhibits DNA gyrase, a bacterial enzyme involved in cell division. METHOD More recently, novobiocin was found to act also on eukaryotic cells by blocking the 90 kDa heat shock protein (Hsp90). Hsp90 is a molecular chaperone, critical for folding, stabilization and activation of… (More)
DOI: 10.2174/1389557516666161223155525


Cite this paper

@article{Dlugosz2017NovobiocinAA, title={Novobiocin Analogs as Potential Anticancer Agents.}, author={Angelika Dlugosz and Anna Janecka}, journal={Mini reviews in medicinal chemistry}, year={2017}, volume={17 9}, pages={728-733} }