Novel variants in the SOHLH2 gene are implicated in human premature ovarian failure.

@article{Qin2014NovelVI,
  title={Novel variants in the SOHLH2 gene are implicated in human premature ovarian failure.},
  author={Yingying Qin and Xue Jiao and Raymond Dalgleish and Svetlana Vujovi{\'c} and Jin Li and Joe Leigh Simpson and Farook al-Azzawi and Zi-Jiang Chen},
  journal={Fertility and sterility},
  year={2014},
  volume={101 4},
  pages={
          1104-1109.e6
        }
}
OBJECTIVE To determine whether variants in the SOHLH2 gene contribute to human premature ovarian failure (POF) in different ethnicities. DESIGN Case-control genetic study. SETTING University hospitals. PATIENT(S) Chinese (364 cases) and Serbian (197 cases) women with nonsyndromic POF and ethnically matched controls. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) Variation analysis of the SOHLH2 gene. RESULT(S) Eleven novel heterozygous variants were identified in cohorts of POF but… CONTINUE READING

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