Novel variants in growth differentiation factor 9 in mothers of dizygotic twins.

@article{Palmer2006NovelVI,
  title={Novel variants in growth differentiation factor 9 in mothers of dizygotic twins.},
  author={James Henry Stuart Palmer and Zhen Zhen Zhao and C William Hoekstra and Nicholas Hayward and Penelope M Webb and David C Whiteman and Nicholas G. Martin and Dorret I. Boomsma and David L Duffy and Grant W. Montgomery},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 11},
  pages={
          4713-6
        }
}
CONTEXT Genes from the ovarian bone morphogenetic signaling pathway (GDF9 and BMP15) are critical for normal human fertility. We previously identified a deletion mutation in GDF9 in sisters with spontaneous dizygotic (DZ) twins, but the prevalence of rare GDF9 variants in twinning families is unknown. OBJECTIVE The objective was to evaluate the frequency of rare variants in GDF9 in families with a history of DZ twinning. DESIGN AND SUBJECTS We recruited 3450 individuals from 915 DZ twinning… CONTINUE READING

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