Novel vaccination protocol with two live mucosal vectors elicits strong cell-mediated immunity in the vagina and protects against vaginal virus challenge.

@article{Li2008NovelVP,
  title={Novel vaccination protocol with two live mucosal vectors elicits strong cell-mediated immunity in the vagina and protects against vaginal virus challenge.},
  author={Zhongxia Li and Manxin Zhang and Chenghui Zhou and Xinyan Zhao and Norifumi Iijima and Fred R. Frankel},
  journal={Journal of immunology},
  year={2008},
  volume={180 4},
  pages={2504-13}
}
Most HIV infections result from heterosexual transmission to women. Because cellular immunity plays a key role in the control of the infection, we sought to strengthen cellular immune responses in vaginal tissue. We explored a novel prime-boost protocol that used two live mucosal agents that trigger different pathways of innate immunity and induce strong… CONTINUE READING