Novel type of proliferating lymphoplasmacytoid cell with a characteristic spotted immunofluorescence pattern.

  title={Novel type of proliferating lymphoplasmacytoid cell with a characteristic spotted immunofluorescence pattern.},
  author={Henk M. Lokhorst and Stella S. G. E. van Boom and Bert E. J. E. G. Bast and Peter J Peters and Thomas F. Tedder and Johannes Gerdes and Eskild Petersen and Rudy E. Ballieux},
  journal={The Journal of clinical investigation},
  volume={79 5},
We examined bone marrow from myeloma patients for the presence of cells with the characteristics of the clonogenic cell in the myeloma stem cell assay. We identified a novel type of cell that contained cytoplasmic immunoglobulin of the relevant idiotype located in a cytoplasmic spot. This "spotted" Ig could be located in the rough endoplasmic reticulum. Spotted cells are highly proliferative, as evidenced by the nuclear staining with the antibody Ki67, and were found in the bone marrow from… CONTINUE READING
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