Novel type of monoclonal antibodies against cyclic GMP and application to immunocytochemistry of the rat brain.

@article{Sakaue1988NovelTO,
  title={Novel type of monoclonal antibodies against cyclic GMP and application to immunocytochemistry of the rat brain.},
  author={Motoyoshi Sakaue and T AKAFUMI Kuno and Chie Tanaka},
  journal={Japanese journal of pharmacology},
  year={1988},
  volume={48 1},
  pages={47-56}
}
A novel type of monoclonal antibodies against cyclic GMP were produced to study the immunocytochemical distribution of cyclic GMP in the rat brain. Cyclic GMP conjugated to bovine serum albumin with glutaraldehyde was used as an immunogen, and monoclonal antibodies were produced. The one monoclonal antibody which did not crossreact against other nucleotides was applied to the immunocytochemistry of the rat brain. Cyclic GMP immunoreactivities were distributed unevenly in the rat brain. The… CONTINUE READING