Novel tumor subgroups of urothelial carcinoma of the bladder defined by integrated genomic analysis.

Abstract

PURPOSE There is a need for improved subclassification of urothelial carcinoma (UC) at diagnosis. A major aim of this study was to search for novel genomic subgroups. EXPERIMENTAL DESIGN We assessed 160 tumors for genome-wide copy number alterations and mutation in genes implicated in UC. These comprised all tumor grades and stages and included 49 high… (More)
DOI: 10.1158/1078-0432.CCR-12-1807

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