Novel triphilic block copolymers based on poly(2-methyl-2-oxazoline)–block–poly(2-octyl-2-oxazoline) with different terminal perfluoroalkyl fragments: Synthesis and self-assembly behaviour

  title={Novel triphilic block copolymers based on poly(2-methyl-2-oxazoline)–block–poly(2-octyl-2-oxazoline) with different terminal perfluoroalkyl fragments: Synthesis and self-assembly behaviour},
  author={Leonid I Kaberov and Bart Verbraeken and Martin Hrub{\'y} and A. O. Riabtseva and Lubom{\'i}r Kov{\'a}{\vc}ik and Sami Kere{\"i}che and Jiř{\'i} Brus and Petr {\vS}těp{\'a}nek and Richard Hoogenboom and Sergey K. Filippov},
  journal={European Polymer Journal},

Fluorophilic–Lipophilic–Hydrophilic Poly(2-oxazoline) Block Copolymers as MRI Contrast Agents: From Synthesis to Self-Assembly

This work focuses on the synthesis and self-assembly of triphilic poly(2-oxazoline) triblock copolymers with high fluorine content toward our future aim of developing poly(2-oxazoline) magnetic

Tuning of Thermoresponsivity of a Poly(2-alkyl-2-oxazoline) Block Copolymer by Interaction with Surface-Active and Chaotropic Metallacarborane Anion.

Thermoresponsive nanoparticles based on the interaction of metallacarboranes, bulky chaotropic and surface-active anions, and poly(2-alkyl-2-oxazoline) block copolymers were prepared, whereby an increase in temperature leads to higher polymer mobility and COSAN release.

Comb-Like Fluorophilic-Lipophilic-Hydrophilic Polymers for Nanocapsules as Ultrasound Contrast Agents.

The results highlight the benefit of adding comb-like fluorinated blocks in PEG-PLA polymers to modify the nanostructure and enhance the echogenicity of nanocapsules intended as UCAs.

Thermo and pH dual-responsive drug-linked pseudo-polypeptide micelles with a comb-shaped polymer as a micellar exterior

The CPiPrOx-b-PAA-DOX micelles showed a pH-responsive DOX release in vitro; this confirmed the acid-liable effect of the acylhydrazone bond that linked the linear PAA block with DOX.

Impact of Polylactide Fluorinated End-Group Lengths and Their Dynamics on Perfluorohexane Microcapsule Morphology

We have synthesized polylactide (PLA) polymers containing five distinct lengths of fluorinated end-groups (from C3F7 to C13F27). The influence of fluorinated end-group lengths and their dynamics in

Engineering of pH-triggered nanoplatforms based on novel poly(2-methyl-2-oxazoline)-b-poly[2-(diisopropylamino)ethyl methacrylate] diblock copolymers with tunable morphologies for biomedical applications

CROP and RAFT polymerization was used to produce PMeOxm-b-PDPAn block copolymers. The microfluid technique enabled the manufacturing of pH-triggered nanoplatforms with different morphologies as

Polyoxazoline associated with cardanol for bio‐based linear alkyl benzene surfactants

Well-defined linear alkyl benzene (LAB) surfactants (COx n ) were successfully synthesized using cardanol as green phenolic alternative and initiator for polyoxazoline (POx) hydrophilic block of the



Synthesis of Monoalkyl End-Capped Poly(2-methyl-2-oxazoline) and Its Micelle Formation in Aqueous Solution

Novel monoalkyl end-capped poly(2-methyl-2-oxazoline) (POXZ-C12 and POXZ-C18), with molecular weights varying from 5500 to 8500, were synthesized by the use of the “initiator method”. The micellar

Temperature Response of Self-Assembled Micelles of Telechelic Hydrophobically Modified Poly(2-alkyl-2-oxazoline)s in Water

Hydrophobically end-modified (HM) poly(2-ethyl-2-oxazolines) (PEtOx) and poly(2-isopropyl-2-oxazolines) (PiPrOx) bearing an n-octadecyl chain on both termini or on one chain end only were prepared by

Synthesis and micellar self-assembly of ternary hydrophilic-lipophilic-fluorophilic block copolymers with a linear PEO chain.

In these multicompartment micelles, it appears that extended nonspherical domains, presumably made of nanocrystallites of the fluorocarbon block, are embedded in the hydrocarbon matrix forming the spherical micellar core.

Synthesis of Ternary, Hydrophilic—Lipophilic—Fluorophilic Block Copolymers by Consecutive RAFT Polymerizations and Their Self-Assembly into Multicompartment Micelles

Linear amphiphilic diblock and ternary triblock copolymers were synthesized by the RAFT method in three successive steps, using oligo(ethylene oxide) monomethyl ether acrylate, butyl or 2-ethylhexyl

Multiple micellar morphologies from tri‐ and tetrablock copoly(2‐oxazoline)s in binary water–ethanol mixtures

We report on the micellization behavior of tri- and tetrablock copoly(2-oxazoline)s in water-ethanol mixtures. The copolymers are based on different combinations of 2-methyl-, 2-ethyl-, 2-phenyl-,

Poly(2-oxazoline)s: a polymer class with numerous potential applications.

A revival of poly(2-oxazoline)s has arisen because of their potential use as biomaterials and thermoresponsive materials, as well as the easy access to defined amphiphilic structures for (hierarchical) self-assembly.

Micellar Structures of Hydrophilic/Lipophilic and Hydrophilic/Fluorophilic Poly(2-oxazoline) Diblock Copolymers in Water

Amphiphilic poly(2-alkyl-2-oxazoline) diblock copolymers of 2-methyl-2-oxazoline (MOx) building the hydrophilic block and either 2-nonyl-2-oxazoline (NOx) for the hydrophobic or

Block copolymers derived from photoreactive 2-oxazolines, 1. Synthesis and micellization behavior

Amphiphilic block copolymers (BCPs) were synthesized consisting of hydrophilic poly(2-methyl-2-oxazoline) blocks and hydrophobic poly(2-alkyl-2-oxazoline) blocks with undecyl-, phenyl-, and the

Synthesis, microwave-assisted polymerization, and polymer properties of fluorinated 2-phenyl-2-oxazolines: a systematic study.

The synthesis and ability of fluorinated 2-phenyl-2-oxazolines to undergo polymerization reflects a strong sensitivity to the quantity of fluorine substituents in general and the presence or absence of ortho-fluoro substitution of the phenyl ring in particular.