Novel treatments for chronic lymphocytic leukemia and moving forward.

  title={Novel treatments for chronic lymphocytic leukemia and moving forward.},
  author={Jennifer Rose Brown and David L. Porter and Susan M O'Brien},
  journal={American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting},
The last several years have seen an explosion of novel therapies for chronic lymphocytic leukemia (CLL). These include the antibody obintutuzumab (GA-101), as well as small-molecule inhibitors of key pathways involved in the pathogenesis of CLL, specifically the B-cell receptor (BCR) pathway (especially Bruton's tyrosine kinase [BTK] and P13K), and the antiapoptotic pathway (especially BCL-2). We will consider each in turn, focusing on the molecules most advanced in clinical development. There… CONTINUE READING


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