Novel treatment strategies in clear-cell metastatic renal cell carcinoma.

  title={Novel treatment strategies in clear-cell metastatic renal cell carcinoma.},
  author={D J van Spronsen and K J M de Weijer and Peter F A Mulders and Pieter H M de Mulder},
  journal={Anti-cancer drugs},
  volume={16 7},
Metastatic renal-cell carcinoma (mRCC) is highly resistant to cytotoxic agents or hormones and is currently mainly treated with cytokine-based therapy. Transient responses and moderate survival advantages have been achieved in a subset of patients with these aspecific biological response modifiers. Side-effects are considerable, especially with high-dose interleukin (IL)-2. Efforts made in the field of specific immunotherapy have focused on optimization of dendritic cell vaccination and on… CONTINUE READING


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