Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors.

@article{Aarts2003NovelTO,
  title={Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors.},
  author={Michelle M. Aarts and M Tymianski},
  journal={Biochemical pharmacology},
  year={2003},
  volume={66 6},
  pages={877-86}
}
Glutamate signalling plays key physiological roles in excitatory neurotransmission and CNS plasticity, but also mediates excitotoxicity, the process responsible for triggering neurodegeneration through glutamate receptor overactivation. Excitotoxicity is thought to be a key neurotoxic mechanism in neurological disorders, including brain ischemia, CNS trauma and epilepsy. However, treating excitotoxicity using glutamate receptor antagonists has not proven clinically viable, necessitating more… CONTINUE READING

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