Novel treatment of chronic severe hand dermatitis with bexarotene gel

@article{Hanifin2004NovelTO,
  title={Novel treatment of chronic severe hand dermatitis with bexarotene gel},
  author={J. Hanifin and V. Stevens and P. Sheth and D. Breneman},
  journal={British Journal of Dermatology},
  year={2004},
  volume={150}
}
Background  Hand dermatitis is an eczematous inflammation of the hands that is related to occupation or to routine activities. It often becomes chronic, and in some patients may become severe and disabling. Topical corticosteroids are effective treatment, particularly for milder forms, but they often lose effectiveness with time and can produce skin atrophy. 
Innovative management of severe hand dermatitis.
The successful treatment of hand dermatitis (HD) depends less on the selection of the proper topical steroid or a particular systemic agent than on addressing any underlying cause or perpetuatingExpand
Manage hand dermatitis with preventative measures and a stepwise approach to escalating therapy
TLDR
Hand dermatitis (eczema) is a common, but often difficult to diagnose, dermatological condition, with systemic corticosteroids and other immunosuppressive agents being reserved for the treatment of more severe disease. Expand
Update on Hand Eczema with Special Focus on the Impact of Moisturisers
TLDR
Although clinical experience suggests an important role for moisturisers, more controlled studies are considered essential to support this scientifically, the development of topical agents that improve skin barrier function is a promising approach for the management of hand dermatitis. Expand
Hyperkeratotic Eczema (Psoriasis) of the Palms
TLDR
Chronic, scaly, hyperkeratotic, fissure-prone, erythematous plaques on the palms and palmar surfaces of the fingers. Expand
Systemic and Topical Treatment of Hand Eczema: Less Well-Established Agents
TLDR
Patients with limited therapeutic options may use topical bexarotene, systemic steroids, ranitidine, vitamin E, azathioprine, disulfiram, disodium cromoglycate, zinc sulfate, iron, or biologics to achieve control of symptoms. Expand
Hand dermatitis/eczema: Current management strategy
TLDR
Dermatitis/eczema are synonymous, often used to indicate a polymorphic pattern of the inflammation of the skin, characterized by pruritus, erythema and vesiculation, a spectrum delineated into acute sub‐acute and chronic dermatitis of the hands. Expand
Alitretinoin for the treatment of chronic hand eczema: clinical rationale
TLDR
This review summarizes the advances on oral alitretinoin for the treatment of severe CHE, with emphasis on its particular benefit for hyperkeratotic hand eczema, and discusses pharmacodynamics and pharmacokinetics, clinical trials and knowledge gaps. Expand
[Management of chronic hand eczema].
  • M. Lahfa
  • Medicine
  • Annales de dermatologie et de venereologie
  • 2014
TLDR
The management of hand eczema, more readily called chronic hand dermatitis, is complex and the repeated therapeutic failures are ransom of incorrect information about the disease and its environment, a lack of clarity in the prescription and duration of treatment in general too short. Expand
Hand dermatitis: current treatment options.
Avoidance advice: This forms a very important component of treatment once a diagnosis of contact dermatitis has been made on the basis of a detailed history, examination and patch testing. PossibleExpand
New and existing therapeutic options for hand eczema.
TLDR
The new and existing treatments that are available for hand eczema are reviewed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 25 REFERENCES
Chronic eczematous dermatitis of the hands: a comparison of PUVA and UVB treatment.
TLDR
PUVA and UVB treatments are alternative treatment modalities in patients with recalcitrant chronic eczematous dermatitis of the hands and PUVA is superior to UVB. Expand
Hand dermatitis. The perennial scourge.
TLDR
Recurring recurrences of hand eczema are frequent, and efforts to avoid the irritant, protect the hands, and use emollients are vital in preventing recurrence. Expand
Hand dermatitis: practical management and current concepts.
  • E. Epstein
  • Medicine
  • Journal of the American Academy of Dermatology
  • 1984
TLDR
With perceptive persistence, most chronic HD can be effectively controlled, and often it means restoring a social and economic outcast to a useful and happy life. Expand
Pimecrolimus cream 1%: a new development in nonsteroid topical treatment of inflammatory skin diseases.
TLDR
Pimecrolimus cream 1% was applied at the first signs and symptoms of eczema to prevent the progression of AD to flares, reducing or completely eliminating the need for topical corticosteroids during a 1-year treatment period. Expand
Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents.
TLDR
Pimecrolimus cream 1% appears to be a safe and effective alternative to currently used therapies for AD and atopic dermatitis in children and adults. Expand
Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part I, efficacy.
TLDR
Tacrolimus ointment-treated patients showed significantly greater improvement than vehicle- treated patients for all efficacy parameters evaluated, including the %BSA affected, the total score and individual scores for signs of atopic dermatitis, the patient's assessment of pruritus, and EASI score. Expand
A clinical trial of tacrolimus ointment for the treatment of atopic dermatitis in adult patients
TLDR
Tacrolimus ointment is a safe and effective medicine for the treatment of adult patients with atopic dermatitis and the significant benefits in the terms of life quality with atopy dermatitis were obtained after treatment. Expand
Topical tacrolimus (FK506) and mometasone furoate in treatment of dyshidrotic palmar eczema: a randomized, observer-blinded trial.
TLDR
Treatment with FK506 offers the possibility for rotational therapy with mometasone furoate in long-standing cases of chronic dyshidrotic palmar eczema. Expand
Successful Treatment of Chronic Hand Eczema with Oral 9-cis-Retinoic Acid
TLDR
9-cis-RA is a valuable drug when given at low doses to patients with chronic hand eczema in a pilot study in an exploratory open-label study. Expand
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
TLDR
Overall intra‐evaluator reliability of the EASI was in the fair‐to‐good range and there was consistency among the evaluators between consecutive days of evaluation, which support the use of theEASI in clinical trials of therapeutic agents for AD. Expand
...
1
2
3
...