Novel thiourea compounds as dual-function microbicides.

  title={Novel thiourea compounds as dual-function microbicides.},
  author={Osmond J. D'Cruz and Taracad K Venkatachalam and Fatih M. Uckun},
  journal={Biology of reproduction},
  volume={63 1},
Sexually active women represent the fastest growing human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome risk group. In an effort to develop a vaginal microbicidal contraceptive potentially capable of preventing HIV transmission as well as providing fertility control, we previously reported the synthesis of novel nonnucleoside inhibitors (NNIs) of HIV-1 reverse transcriptase with sperm-immobilizing activity (SIA). To gain further insight into the structure-function relationship… CONTINUE READING
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