Novel thermosensitive pentablock copolymers for sustained delivery of proteins in the treatment of posterior segment diseases.

@article{Patel2014NovelTP,
  title={Novel thermosensitive pentablock copolymers for sustained delivery of proteins in the treatment of posterior segment diseases.},
  author={Sulabh Patel and Ravi Vaishya and Xiaoyan Yang and Dhananjay Pal and Ashim K Mitra},
  journal={Protein and peptide letters},
  year={2014},
  volume={21 11},
  pages={1185-200}
}
Biodegradable and injectable in situ thermosensitive hydrogels were investigated for sustained delivery of pro- tein therapeutics in the treatment of ocular posterior segment neovascular diseases. A series of triblock (TB, polycaprolac- tone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL), B-A-B) and pentablock copolymers (PBCs) (polylactic acid (PLA)-PCL-PEG-PCL-PLA (C-B-A-B-C) and PEG-PCL-PLA-PCL-PEG (A-B-C-B-A)) were synthesized and evaluated for their thermosensitive behavior. Effects of… CONTINUE READING