Novel thermo- and pH-responsive hydroxypropyl cellulose- and poly (L-glutamic acid)-based microgels for oral insulin controlled release.

@article{Bai2012NovelTA,
  title={Novel thermo- and pH-responsive hydroxypropyl cellulose- and poly (L-glutamic acid)-based microgels for oral insulin controlled release.},
  author={Yunyan Bai and Zhe Zhang and Aiping Zhang and Li Chen and Chaoliang He and Xiuli Zhuang and Xuesi Chen},
  journal={Carbohydrate polymers},
  year={2012},
  volume={89 4},
  pages={
          1207-14
        }
}
Novel smart microgel particles made of poly (L-glutamic acid-2-hydroxylethyl methacrylate) (PGH) and hydroxypropyl cellulose-acrylic acid (HPC-AA) have been successfully prepared via emulsion polymerization. The dynamic light scattering measurement reveals that the average hydrodynamic radius 〈Rh〉 and hydrodynamic radius distributions f (Rh) of the microgel particles depend on the temperature and pH value thus the microgel particles exhibit both pH- and temperature-sensitivity. In vitro release… CONTINUE READING

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