Novel therapies for inflammatory bowel disease.

  title={Novel therapies for inflammatory bowel disease.},
  author={Bruce E Sands},
  journal={Gastroenterology clinics of North America},
  volume={28 2},
  • Bruce E Sands
  • Published 1999 in Gastroenterology clinics of North America
Looking back at successes and failures in newer approaches to treating IBD, it is tempting--although still difficult--to draw conclusions about pathogenesis. When a therapy proves effective, do clinicians truly know how it works? Even with a therapy as specific as anti-TNF antibody, it is not clear if the benefit is attributable to simple binding and clearance of TNF-alpha or to binding on the cell surface and subsequent deletion of the activated macrophage. When a drug appears to be less… CONTINUE READING


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