Novel therapies for chronic lymphocytic leukemia.

  title={Novel therapies for chronic lymphocytic leukemia.},
  author={Blanche H Mavromatis and Bruce D Cheson},
  journal={Blood reviews},
  volume={18 2},
New therapies for chronic lymphocytic leukemia (CLL) are moving away from non-specific cytotoxic to more targeted approaches. The monoclonal antibody alemtuzumab induces responses in 33% to 43% of patients with relapsed or refractory disease, with 2-5% CR. Side effects include infusional reactions as well as immunosuppressive effects. Rituximab has limited activity in relapsed refractory patients, but response rates are comparable to follicular non-Hodgkin's lymphoma in untreated patients… CONTINUE READING
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