Novel therapies focused on the high-density lipoprotein particle.

  title={Novel therapies focused on the high-density lipoprotein particle.},
  author={Julian C. van Capelleveen and Hollis B Brewer and John J. P. Kastelein and G. K. Hovingh},
  journal={Circulation research},
  volume={114 1},
Cardiovascular disease (CVD) remains a major burden for morbidity and mortality in the general population, despite current efficacious low-density lipoprotein-cholesterol-lowering therapies. Consequently, novel therapies are required to reduce this residual risk. Prospective epidemiological studies have shown that high-density lipoprotein-cholesterol (HDL-C) levels are inversely correlated with cardiovascular disease risk, and this initiated the quest for HDL-C-increasing therapies… CONTINUE READING


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Presentation: IV single-dose ACP-501 (rhLCAT) is well-tolerated, raises HDL-C in those with low HDL with CAD

  • R. Shamburek
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