Novel therapeutic target: the PERKs of inhibiting the integrated stress response.

@article{Blais2006NovelTT,
  title={Novel therapeutic target: the PERKs of inhibiting the integrated stress response.},
  author={Jaime D Blais and John C. Bell},
  journal={Cell cycle},
  year={2006},
  volume={5 24},
  pages={2874-7}
}
Oxygen supports the life of all aerobic organisms and virtually every cell type is capable of sensing decreased tissue oxygenation or hypoxia. Hypoxic microenvironments are known to exist within developing solid tumors as a result of insufficient vascular delivery of oxygen, which can limit the efficient growth and spread of the malignancy. On the other hand, clinical and experimental evidence has demonstrated that reduction in tumor blood flow can diminish the efficacy of standard anticancer… CONTINUE READING