Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade.

@article{Trevisan2013NovelTS,
  title={Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade.},
  author={Gabriela Trevisan and Serena Materazzi and Camilla Fusi and Alessandra A. Altomare and Giancarlo Aldini and Maura Lodovici and Riccardo Patacchini and Pierangelo Geppetti and Romina Nassini},
  journal={Cancer research},
  year={2013},
  volume={73 10},
  pages={3120-31}
}
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and painful adverse reaction of cancer treatment in patients that is little understood or treated. Cytotoxic drugs that cause CIPN exert their effects by increasing oxidative stress, which activates the ion channel TRPA1 expressed by nociceptors. In this study, we evaluated whether TRPA1 acted as a critical mediator of CIPN by bortezomib or oxaliplatin in a mouse model system. Bortezomib evoked a prolonged mechanical, cold, and… CONTINUE READING