Novel tetracycline resistance determinant isolated from an environmental strain of Serratia marcescens.

@article{Thompson2007NovelTR,
  title={Novel tetracycline resistance determinant isolated from an environmental strain of Serratia marcescens.},
  author={Stuart A Thompson and Elizabeth V Maani and Angela H. Lindell and Catherine J. King and J V McArthur},
  journal={Applied and environmental microbiology},
  year={2007},
  volume={73 7},
  pages={2199-206}
}
Resistances to tetracycline and mercury were identified in an environmental strain of Serratia marcescens isolated from a stream highly contaminated with heavy metals. As a step toward addressing the mechanisms of coselection of heavy metal and antibiotic resistances, the tetracycline resistance determinant was cloned in Escherichia coli. Within the cloned 13-kb segment, the tetracycline resistance locus was localized by deletion analysis and transposon mutagenesis. DNA sequence analysis of an… CONTINUE READING

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