Novel terpenoids, trichoderonic acids A and B isolated from Trichoderma virens, are selective inhibitors of family X DNA polymerases.

@article{Yamaguchi2010NovelTT,
  title={Novel terpenoids, trichoderonic acids A and B isolated from Trichoderma virens, are selective inhibitors of family X DNA polymerases.},
  author={Yasuhiro Yamaguchi and Daisuke Manita and Toshifumi Takeuchi and Kouji Kuramochi and Isoko Kuriyama and Fumio Sugawara and Hiromi Yoshida and Yoshiyuki Mizushina},
  journal={Bioscience, biotechnology, and biochemistry},
  year={2010},
  volume={74 4},
  pages={793-801}
}
Trichoderonic acids A (1) and B (2), novel terpenoids, and (+)-heptelidic acid (3) isolated from cultures of a fungus, Trichoderma virens, and their structures were identified by spectroscopic analysis. These compounds selectively and competitively inhibited the activities of mammalian DNA polymerases beta, lambda (pols beta, lambda), and terminal deoxynucleotidyl transferase (TdT) in family X of pols, and compound 2 was a stronger inhibitor than compound 1 or 3. On the other hand, compounds 1… CONTINUE READING