Novel teicoplanins by directed biosynthesis.

  title={Novel teicoplanins by directed biosynthesis.},
  author={Ameriga Lazzarini and A Borghi and Luigi F. Zerilli and Patrizia Ferrari and Luigi Pietro Maria Colombo and G. C. Lancini},
  journal={The Journal of antibiotics},
  volume={50 2},
Teicoplanin1*, a clinically useful glycopeptide antibiotic(2), is produced by Actinoplanes teichomyceticus as a complex of five main components, denoted factors A2-1 to A2-5, differing in the structure of their acyl side chain, which is linear in A2-1 and A2-3 and branched in the other components3). In a previous paper40 it was shown that the acyl moieties of the teicoplanin complexoriginate from stepwise shortening, through the usual /?oxidation mechanism, of long chain fatty acids… CONTINUE READING

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