Novel targets in Alzheimer's disease: A special focus on microglia.

@article{Balducci2018NovelTI,
  title={Novel targets in Alzheimer's disease: A special focus on microglia.},
  author={Claudia Balducci and Gianluigi Forloni},
  journal={Pharmacological research},
  year={2018},
  volume={130},
  pages={402-413}
}
Several years after the intriguing novelty in the β-amyloid (Aβ) cascade hypothesis, where the Aβ oligomers emerged as the most detrimental species in the neuropathogenic process of Alzheimer's disease (AD) in place of fibrillar plaques, more recently innate immune system have come on stage as the other prominent factor. Neuroinflammation apparently contributes to AD eziopathogenesis, in large part through overactivation of microglia cells. Genetic and experimental studies strongly support the… CONTINUE READING