Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-β1-dependent pathway

@article{Jiang2002NovelTF,
  title={Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-β1-dependent pathway},
  author={Xiao-hua Jiang and Shiu-kum Lam and Marie C. M. Lin and Shi-hu Jiang and Hsiang-fu Kung and Eric D. Slosberg and Jae Won Soh and I. Bernard Weinstein and Benjamin Chun-yu Wong},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={6113-6122}
}
Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of gastrointestinal cancers. Recently, a similar protective effect has been demonstrated by the specific cyclo-oxygenase-2 (COX-2) inhibitors. However, the exact mechanism that accounts for the anti-proliferative effect of specific COX-2 inhibitors is still not fully understood, and it is still controversial whether these protective effects are predominantly mediated through the inhibition of COX-2 activity and prostaglandin… CONTINUE READING
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