Novel synthetic inhibitors of selectin-mediated cell adhesion: synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-alpha-D- mannopyranosyloxy)phenyl]hexane (TBC1269).

@article{Kogan1998NovelSI,
  title={Novel synthetic inhibitors of selectin-mediated cell adhesion: synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-alpha-D- mannopyranosyloxy)phenyl]hexane (TBC1269).},
  author={Timothy P. Kogan and Brian Dupr{\'e} and Huong Bui and K L McAbee and Judith Kassir and Ian L Scott and Xingding Hu and Peter Vanderslice and Peter J. Beck and Richard A. Dixon},
  journal={Journal of medicinal chemistry},
  year={1998},
  volume={41 7},
  pages={1099-111}
}
Reports of a high-affinity ligand for E-selectin, sialyl di-Lewis(x) (sLe(x)Le(x), 1), motivated us to incorporate modifications to previously reported biphenyl-based inhibitors that would provide additional interactions with the protein. These compounds were assayed for the ability to inhibit the binding of sialyl Lewis(x) (sLe(x), 2) bearing HL-60 cells to E-, P-, and L-selectin fusion proteins. We report that dimeric or trimeric compounds containing multiple components of simple… CONTINUE READING

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