Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells.

@article{Nam2012NovelSD,
  title={Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells.},
  author={Sangkil Nam and Jun Xie and Angela L. Perkins and Yuelong Ma and Fan Yang and Jun Wu and Yanli Wang and Rong-zhen Xu and Wendong Huang and David A. Horne and Richard Jove},
  journal={Molecular oncology},
  year={2012},
  volume={6 5},
  pages={484-93}
}
Persistent Jak/Stat3 signal transduction plays a crucial role in tumorigenesis and immune development. Activated Jak/Stat3 signaling has been validated as a promising molecular target for cancer therapeutics discovery and development. Berbamine (BBM), a natural bis-benzylisoquinoline alkaloid, was identified from the traditional Chinese herbal medicine Berberis amurensis used for treatment of cancer patients. While BBM has been shown to have potent antitumor activities with low toxicity in… CONTINUE READING
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