Novel synthetic bisbenzimidazole that targets angiogenesis in Ehrlich ascites carcinoma bearing mice.

@article{Roopashree2015NovelSB,
  title={Novel synthetic bisbenzimidazole that targets angiogenesis in Ehrlich ascites carcinoma bearing mice.},
  author={Rangaswamy Roopashree and Chakrabhavi Dhananjaya Mohan and Toreshettahally Ramesh Swaroop and Swamy Jagadish and Byregowda Raghava and Kyathegowdanadoddi Srinivas Balaji and Shankar Jayarama and Basappa and Kanchugarakoppal Subbegowda Rangappa},
  journal={Bioorganic & medicinal chemistry letters},
  year={2015},
  volume={25 12},
  pages={2589-93}
}
Cancer is a leading cause of death in developed countries and second cause in developing countries. Herein we are reporting the synthesis of novel bisbenzimidazole derivatives and their anticancer properties. Among the newly synthesized bisbenzimidazoles, 3-(4-flurophenylsulfonyl)-1,7-dimethyl-2-propyl-1H,3H-2,5-bibenzo[d]imidazole (FDPB) presented as a potent antiproliferative agent against HeLa, HCT116 and A549 cells with selectivity over normal Vero cells (IC50 >50 μM). Additionally, we… CONTINUE READING
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