Novel synthesis and characterization of bioconjugate block copolymers having oligonucleotides.

@article{Noro2005NovelSA,
  title={Novel synthesis and characterization of bioconjugate block copolymers having oligonucleotides.},
  author={Atsushi Noro and Yutaka Nagata and Masaki Tsukamoto and Yoshihiro Hayakawa and Atsushi Takano and Yushu Matsushita},
  journal={Biomacromolecules},
  year={2005},
  volume={6 4},
  pages={
          2328-33
        }
}
Novel and efficient synthesis of polymers terminated with nucleotides via the phosphoramidite method has been developed. A hydroxyl-terminated polymer was converted into a polymer capped with a nucleotide in three steps, where the conversion of the reactions was very high, almost 100%. By repetition of this synthetic method, a block copolymer composed of a synthetic polymer, polystyrene, and biological oligonucleotides with thymidine units has been successfully synthesized. A microphase… 
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