Novel synthesis and characterization of bioconjugate block copolymers having oligonucleotides.

@article{Noro2005NovelSA,
  title={Novel synthesis and characterization of bioconjugate block copolymers having oligonucleotides.},
  author={Atsushi Noro and Yutaka Nagata and Masaki Tsukamoto and Yoshihiro Hayakawa and Atsushi Takano and Yushu Matsushita},
  journal={Biomacromolecules},
  year={2005},
  volume={6 4},
  pages={
          2328-33
        }
}
Novel and efficient synthesis of polymers terminated with nucleotides via the phosphoramidite method has been developed. A hydroxyl-terminated polymer was converted into a polymer capped with a nucleotide in three steps, where the conversion of the reactions was very high, almost 100%. By repetition of this synthetic method, a block copolymer composed of a synthetic polymer, polystyrene, and biological oligonucleotides with thymidine units has been successfully synthesized. A microphase… 
View on PubMed
doi.org
12 Citations

12 Citations

Citation Type

Citation Type

Telechelic polymers by living and controlled/living polymerization methods
Synthesis and self-assembly of polymeric hybrid nanomaterials
  • A. Kamps
  • Materials Science, Chemistry
  • 2012
The ability to construct functional polymeric hybrid nanomaterials is critically important for many applications. In this thesis I present the synthesis of amphiphilic polymers of various…
Hierarchical nanophase-separated structures created by precisely-designed polymers with complexity
Study of properties of some new thermoplastic block copolymers and their corresponding blends with secondary polyethylene
An ABA triblock containing a central soft block of poly[2,5-di(n-hexogycarbonyl)styrene] and outer hard block of poly(4-vinylpyridine): synthesis, phase behavior and mechanical enhancement
We designed and synthesized a series of ABA triblock copolymers containing an inner soft poly[2,5-di(n-hexogycarbonyl)styrene] (PHCS) block and an outer hard poly(4-vinylpyridine) (P4VP) block,…
Design and properties of supramolecular polymer gels
Supramolecular polymer gels are precisely designed physical gels brought together by reversible secondary interactions to form three dimensional networks of melt macromolecules. Generally, they…
Supramolecular Polymers and Networkswith Hydrogen Bonds in the Main- and Side-Chain
Control of polymeric structure is among the most important endeavors of modern macromolecularscience. In particular, tailoring the positioning and strength of intermolecular forces within…
Synthesis of a Bio-based and Biodegradable Poly(ethylene-co-isosorbide [2,2'-bithiophene]-5,5'-dicarboxylate) with enhanced Thermal and Degradability Properties
In this investigation, a synthetic biopolymer prepared from bithiophene monomer, isosorbide and ethylene glycol, was synthesized through melt polycondensation. The result showed the polyesters to…
Order-disorder transition in supramolecular polymers.
TLDR
The long-range order and order-disorder transition (ODT) of main-chain supramolecular polymers based on poly(propylene oxide) (PPO) spacers functionalized on both ends with thymine, accompanied by dramatic flow and mechanical properties changes is reported.
Organisation multi-échelle de matériaux polymères contrôlée par la chimie aux interfaces
Les proprietes des materiaux decoulent en partie de leur organisation a l’echelle nano ou microscopique. Dans cette these, on montre qu’en controlant la chimie aux interfaces, des organisations tres…
...
...