Novel swine-origin influenza A virus in humans: another pandemic knocking at the door

  title={Novel swine-origin influenza A virus in humans: another pandemic knocking at the door},
  author={Martin Michaelis and Hans Wilhelm Doerr and Jindrich Cinatl},
  journal={Medical Microbiology and Immunology},
Influenza A viruses represent a continuous pandemic threat. In April 2009, a novel influenza A virus, the so-called swine-origin influenza A (H1N1) virus (S-OIV), was identified in Mexico. Although S-OIV originates from triple-reassortant swine influenza A (H1) that has been circulating in North American pig herds since the end of the 1990s, S-OIV is readily transmitted between humans but is not epidemic in pigs. After its discovery, S-OIV rapidly spread throughout the world within few weeks… 
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Of chickens and men: avian influenza in humans.
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The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host.
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Cases of swine influenza in humans: a review of the literature.
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The threat of avian influenza A (H5N1). Part I: epidemiologic concerns and virulence determinants
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Transmission of influenza A in human beings.