Novel surface-modified nanostructured lipid carriers with partially deacetylated water-soluble chitosan for efficient ocular delivery.

@article{Tian2012NovelSN,
  title={Novel surface-modified nanostructured lipid carriers with partially deacetylated water-soluble chitosan for efficient ocular delivery.},
  author={Baocheng Tian and Q. Luo and S. Song and D. Liu and H. Pan and Wen-ji Zhang and L. He and Shilin Ma and X. Yang and W. Pan},
  journal={Journal of pharmaceutical sciences},
  year={2012},
  volume={101 3},
  pages={
          1040-9
        }
}
  • Baocheng Tian, Q. Luo, +7 authors W. Pan
  • Published 2012
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • The objective of this study was to propose novel surface-modified nanostructured lipid carriers with partially deacetylated water-soluble chitosan (NLC-PDSC) as an efficient ocular delivery system to improve its transcorneal penetration and precorneal retention. PDSC with a deacetylation degree of around 50% was synthesized using an improved method. NLC loaded with flurbiprofen (FB) were prepared by melt emulsification method. They presented spherical morphology under both transmission electron… CONTINUE READING
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