Novel surface-modified nanostructured lipid carriers with partially deacetylated water-soluble chitosan for efficient ocular delivery.

@article{Tian2012NovelSN,
  title={Novel surface-modified nanostructured lipid carriers with partially deacetylated water-soluble chitosan for efficient ocular delivery.},
  author={Baocheng Tian and Q. Luo and S. Song and D. Liu and H. Pan and Wen-ji Zhang and L. He and Shilin Ma and X. Yang and W. Pan},
  journal={Journal of pharmaceutical sciences},
  year={2012},
  volume={101 3},
  pages={
          1040-9
        }
}
  • Baocheng Tian, Q. Luo, +7 authors W. Pan
  • Published 2012
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
    • The objective of this study was to propose novel surface-modified nanostructured lipid carriers with partially deacetylated water-soluble chitosan (NLC-PDSC) as an efficient ocular delivery system to improve its transcorneal penetration and precorneal retention. PDSC with a deacetylation degree of around 50% was synthesized using an improved method. NLC loaded with flurbiprofen (FB) were prepared by melt emulsification method. They presented spherical morphology under both transmission electron… CONTINUE READING
    View on PubMed
    doi.org
    37 Citations
    Highly Influencial Citations
    1
    Background Citations
    5
    Methods Citations
    5
    37 Citations
    Citation Type

    Citation Type

    Potential advantages of a novel chitosan-N-acetylcysteine surface modified nanostructured lipid carrier on the performance of ophthalmic delivery of curcumin
    • 41
    • PDF
    Nanostructured lipid carrier surface modified with Eudragit RS 100 and its potential ophthalmic functions
    • 32
    Further investigation of nanostructured lipid carriers as an ocular delivery system: in vivo transcorneal mechanism and in vitro release study.
    • 40
    Development of a nanostructured lipid carrier formulation for increasing photo-stability and water solubility of Phenylethyl Resorcinol
    • 56
    Preparation and characterization of chitosan-coated nanostructured lipid carriers (CH-NLC) containing cinnamon essential oil for enriching milk and anti-oxidant activity
    • 6
    In situ gel containing Bimatoprost solid lipid nanoparticles for ocular delivery: In-vitro and ex-vivo evaluation
    • 2
    A novel oral delivery system consisting in "drug-in cyclodextrin-in nanostructured lipid carriers" for poorly water-soluble drug: vinpocetine.
    • 33
    Effect of sterilization on the physical stability of brimonidine-loaded solid lipid nanoparticles and nanostructured lipid carriers.
    • 36
    Nanostructured lipid carriers (NLC) system: A novel drug targeting carrier
    • 28
    A close collaboration of chitosan with lipid colloidal carriers for drug delivery applications
    • 19

    References

    SHOWING 1-10 OF 37 REFERENCES
    Nanostructured lipid carrier (NLC) coated with Chitosan Oligosaccharides and its potential use in ocular drug delivery system.
    • 154
    A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers.
    • 153
    Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery.
    • 195
    A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery.
    • 214
    • PDF
    Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: Improving preocular retention and ocular bioavailability.
    • L. Gan, S. han, +4 authors Y. Gan
    • Chemistry, Medicine
    • International journal of pharmaceutics
    • 2010
    • 127
    Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability.
    • 195
    Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
    • 1,507
    PLGA microspheres for the ocular delivery of a peptide drug, vancomycin using emulsification/spray-drying as the preparation method: in vitro/in vivo studies.
    • 147
    Topical use of chitosan in ophthalmology: tolerance assessment and evaluation of precorneal retention.
    • 305
    Ocular drug delivery by liposome-chitosan nanoparticle complexes (LCS-NP).
    • 211
    • PDF