Novel suppressors of α-synuclein toxicity identified using yeast


The mechanism by which the Parkinson’s disease-related protein a-synuclein (a-syn) causes neurodegeneration has not been elucidated. To determine the genes that protect cells from a-syn, we used a genetic screen to identify suppressors of the super sensitivity of the yeast Saccharomyces cerevisiae expressing a-syn to killing by hydrogen peroxide. Forty… (More)


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Citations per Year

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