Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens.

@article{Qiu2009NovelSO,
  title={Novel subset of CD8\{alpha\}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens.},
  author={Chun-Hong Qiu and Yasunobu Miyake and Hitomi Kaise and Hiroshi Kitamura and Osamu Ohara and Masato Tanaka},
  journal={Journal of immunology},
  year={2009},
  volume={182 7},
  pages={4127-36}
}
Apoptotic cell clearance by dendritic cells (DCs) plays a crucial role in the maintenance of self-tolerance. In spleen, CD8alpha(+) DCs are thought to be responsible for this phenomenon by phagocytosing circulating apoptotic cells. However, as CD8alpha(+) DCs are believed to be predominantly localized in the T cell zone, it remains unclear how these DCs phagocytose blood-borne apoptotic cells accumulated in the marginal zone (MZ). In this study, we identified a subpopulation of CD8alpha(+) DCs… CONTINUE READING
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