Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63

@article{Horejsi1991NovelSD,
  title={Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63},
  author={V. Horejsi and {\vC}. Vl{\vc}ek},
  journal={FEBS Letters},
  year={1991},
  volume={288}
}
Several of the recently described leucocyte surface (glyco)‐proteins with significant amino acid sequence similarity (human CD9, CD37, CD53, CD63, TAPA‐1, CO‐029 and R2 and several homologues of other species) are distinguished by the polypeptide chain apparently four times crossing the membrane. Although the biological role of none of these molecules is known, their structure, associations with other membrane components and the effects of specific monoclonal antibodies suggest that they may… Expand
The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes
TLDR
The CD37, CD53, and R2 leukocyte surface antigens genes were assigned with the help of human/rodent somatic cell hybrids and human-specific probes to human chromosomes 19, 1, and 11, respectively. Expand
Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins
TLDR
Coprecipitation and preclearing experiments indicate the existence of large multicomponent complexes containing jointly the seven components, although some “incomplete” complexes lacking some of the components may also exist. Expand
Characterisation of mouse CD37: cDNA and genomic cloning.
TLDR
Cd37 shows a striking similarity in genomic organisation to other members of the transmembrane 4 superfamily, which is consistent with the theory that this superfamily has evolved by gene duplication and divergence from a common ancestral gene. Expand
MOLECULAR CLONING OF THE MOUSE CD9 ANTIGEN EQUIVALENT OF
TLDR
The cloning and sequencing of a cDNA coding for the mouse CD9 antigen is reported here and there is 89% homology at amino acid level between the human and mouseCD9 molecules. Expand
Platelet p24/CD9, a Member of the Tetraspanin Family of Proteins a
TLDR
It has been demonstrated that the activating activity of antip24/CD9 mAb is inhibited by the preincubation of platelets with a mAb to the Fc receptor on platelets, IV-3, and all anti-p24/ CD9 mAbs described thus far cause platelet activation. Expand
Molecular cloning of the mouse equivalent of CD9 antigen.
TLDR
The cloning and sequencing of a cDNA coding for the mouse CD9 antigen is reported here and there is 89% homology at amino acid level between the human and mouseCD9 molecules. Expand
CD63 associates with CD11/CD18 in large detergent‐resistant complexes after translocation to the cell surface in human neutrophils 1
TLDR
The data suggest that intracellular CD11, CD18 and CD63 are not in detergent‐resistant complexes, but enter such complexes following translocation to the cell surface. Expand
CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells.
TLDR
The results indicate that CD53, like several other leukocyte Ag with four membrane-spanning regions, has the ability to mediate cell activation, and support the view that these molecules are involved in transmembrane communication. Expand
CD82, tetra‐span‐transmembrane protein, is a regulated transducing molecule on U937 monocytic cell line
TLDR
It is demonstrated that cross‐linking of IA4 mAbs induces an increase of intracellular free calcium in U937 cells and tyrosine phosphorylation of various proteins, which suggest that, upon cross‐ linking of CD82, a multimolecular complex including CD82 and FcR could be induced that is able to trigger signal transduction. Expand
Localization of the Transmembrane 4 Superfamily (TM4SF) Member PETA-3 (CD151) in Normal Human Tissues: Comparison with CD9, CD63, and α5β1 Integrin
TLDR
The findings of this study show co-localization of PETA-3 with CD9, CD63, α5β1, and β1 in particular tissues, demonstrating that tetraspan/integrin complexes may occur. Expand
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