Novel strand exchanges in V(D)J recombination

  title={Novel strand exchanges in V(D)J recombination},
  author={Susanna M. Lewis and Joanne E Hesse and Kiyoshi Mizuuchi and Martin Gellert},
We describe novel products of V(D)J recombination in which signal sequences become joined to coding elements, in contrast to the standard reaction whose products are junctions of two signal sequences or two coding elements. In this variant reaction, the recombination machinery evidently recognizes signal sequences and introduces strand breaks at the normal positions, but then connects the elements in unusual combinations. The lack of fixed directionality indicates that recombination sites are… CONTINUE READING


Publications citing this paper.
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Publications referenced by this paper.
Showing 1-10 of 22 references

The defect

  • Mizuuchr, K.. Bosma, J M., M Gellert.
  • 1988

Two pairs of recombma

  • S. Akira, K Okazaki., H. Sakano
  • 1987
1 Excerpt

DNA: the effect of single base pair mismatch

  • T. Manser, M. L. Gefter
  • Nucl. Acids Res
  • 1986

Direct evidence for chromosomal inversion during T-cell receptor

  • M. Malissen, C. McCoy, +6 authors B. Malissen
  • b-gene rearrangements. Nature
  • 1986
1 Excerpt

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