Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells.

@article{Moore2003NovelSR,
  title={Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells.},
  author={Michael G Moore and Lawrence A Wetterau and Malik Joseph Francis and Donna M. Peehl and Pinchas Cohen},
  journal={International journal of cancer},
  year={2003},
  volume={105 1},
  pages={
          14-9
        }
}
The insulin-like growth factor (IGF) axis is a complex system composed of 2 mitogenic ligands, IGF-I and -II, 2 receptors, IGF-1R and IGF-2R, and 6 binding proteins, IGFBP-1 to -6. The IGFBPs exert their actions through their regulation of IGF bioavailability for IGF receptors. In addition, some IGFBPs have also been found to have direct cellular actions independent of IGFs. IGFBP-2 is a major IGFBP in the prostate and in seminal fluid. IGFBP-2 levels, which are elevated in many malignancies… CONTINUE READING
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