Novel stimulatory actions of the phytoestrogen genistein: effects on the gain of cardiac excitation-contraction coupling.

@article{Liew2003NovelSA,
  title={Novel stimulatory actions of the phytoestrogen genistein: effects on the gain of cardiac excitation-contraction coupling.},
  author={Reginald Liew and Kenneth T. Macleod and Peter R. Collins},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2003},
  volume={17 10},
  pages={1307-9}
}
Genistein, a phytoestrogen found abundantly in soy products, is thought to be cardioprotective, partly through its ability to act as a natural Ca2+ channel antagonist. However, the precise nature and significance of such direct cardiac actions remain obscure. We investigated the hypothesis that genistein exerts important additional actions on cardiac excitation-contraction coupling (ECC). Genistein acutely increased cell shortening and the Ca2+ transient in field stimulated guinea-pig… CONTINUE READING

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