Novel steroid receptor phyto-modulator compound a inhibits growth and survival of prostate cancer cells.

@article{Yemelyanov2008NovelSR,
  title={Novel steroid receptor phyto-modulator compound a inhibits growth and survival of prostate cancer cells.},
  author={Alexander Yemelyanov and Jennifer L Czwornog and Lajos Gera and Sonali Joshi and Robert Treat Chatterton and Irina V. Budunova},
  journal={Cancer research},
  year={2008},
  volume={68 12},
  pages={
          4763-73
        }
}
Androgen receptor (AR)- and glucocorticoid receptor (GR)- mediated signaling play opposite roles in prostate tumorigenesis: AR promotes prostate carcinoma (PC) development, whereas GR acts as a tumor suppressor. Compound A (CpdA) is a stable analogue of an aziridine precursor from the African shrub Salsola tuberculatiformis Botschantzev. It was shown recently that, in model cells, CpdA inhibits AR function and strongly enhances anti-inflammatory function of GR. We determined the effects of CpdA… CONTINUE READING

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