Novel spirobicyclic artemisinin analogues (artemalogues): Synthesis and antitumor activities.

Abstract

The sesquiterpene lactone framework of artemisinin was used as a drug repositioning prototype for the development of novel antitumor drugs. Several series of novel artemisinin analogues (artemalogues) were designed and synthesized through 1,3-dipolar cycloaddition of artemisitene with nitrile oxides or nitrones. The isoxazolidine-containing spirobicyclic… (More)
DOI: 10.1016/j.ejmech.2015.08.035

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