Novel spiroannulated 3-benzofuranones. Synthesis and inhibition of the human peptidyl prolyl cis/trans isomerase Pin1.

@article{Braun2008NovelS3,
  title={Novel spiroannulated 3-benzofuranones. Synthesis and inhibition of the human peptidyl prolyl cis/trans isomerase Pin1.},
  author={Manfred Braun and Anahita Hessamian-Alinejad and Boris F{\'e}aux de Lacroix and Birte Hernandez Alvarez and Gunter Fischer},
  journal={Molecules},
  year={2008},
  volume={13 4},
  pages={995-1003}
}
The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been made accessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclic benzofuranones 2 and 3, respectively. A four-step synthesis to spirocompound 4 is described. The novel spirocyclic benzofuranones display modest to no inhibition of the human peptidyl prolyl cis/trans isomerase Pin1. 

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