Novel solid lipid nanoparticles as carriers for oral administration of insulin.

@article{Zhang2009NovelSL,
  title={Novel solid lipid nanoparticles as carriers for oral administration of insulin.},
  author={Zhenhai Zhang and Huixia Lv and Jianping Zhou},
  journal={Die Pharmazie},
  year={2009},
  volume={64 9},
  pages={574-8}
}
The aim of this study was to propose novel solid lipid nanoparticles (SLNs) loaded with cell-penetrating peptide (CPP), and to evaluate their potential for oral administration of insulin. Octaarginine (R8) was used as the CPP. SLNs loaded with insulin and R8 (Ra-Ins-SLNs) were prepared using the spontaneous emulsion solvent diffusion method. The morphological study of R8-Ins-SLNs showed its spherical shape using transmission electron microscopy (TEM) photography. The mean particle size, zeta… CONTINUE READING
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