Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders.

@article{Wedel2006NovelSM,
  title={Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders.},
  author={Thilo Wedel and Guillaume J van Eys and David Waltregny and Wendy Gl{\'e}nisson and Vincent Castronovo and J-M Vanderwinden},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2006},
  volume={18 7},
  pages={
          526-38
        }
}
Histopathological studies of gastrointestinal motility disorders have mainly focused on enteric nerves and interstitial cells of Cajal, but rarely considered the enteric musculature. Here we used both classical and novel smooth muscle markers and transmission electron microscopy (TEM) to investigate muscular alterations in severe colorectal motility disorders. Full-thickness specimens from Hirschsprung's disease, idiopathic megacolon, slow-transit constipation and controls were stained with… CONTINUE READING
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