Novel small peptides with neuroprotective and nootropic properties.

  title={Novel small peptides with neuroprotective and nootropic properties.},
  author={Alan I. Faden and Susan Knoblach and Vilen A Movsesyan and Ibolja Cernak},
  journal={Journal of Alzheimer's disease : JAD},
  volume={6 6 Suppl},
The tripeptide thyrotropin-releasing hormone (TRH) and/or related analogues have shown neuroprotective activity across multiple animal trauma models as well as in a small clinical trial of spinal cord injury. The metabolic product of TRH (cyclo-his-pro) retains physiological activity. We have developed a number of novel cyclic dipeptides that are structurally similar to cyclo-his-pro, and have examined their neuroprotective activity across multiple in vitro models of neuronal injury and after… CONTINUE READING


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