Novel small molecules potentiate premature termination codon readthrough by aminoglycosides

Abstract

Nonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene function by eliciting premature termination codon readthrough but with low efficiency. Using a high-throughput screen, we identified compounds that potentiate readthrough by aminoglycosides at multiple… (More)
DOI: 10.1093/nar/gkw638

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@inproceedings{BaradaranHeravi2016NovelSM, title={Novel small molecules potentiate premature termination codon readthrough by aminoglycosides}, author={Alireza Baradaran-Heravi and Aruna D. Balgi and Carla A. Zimmerman and Kunho Choi and Fahimeh S. Shidmoossavee and Jason Samuel Tan and C{\'e}lia Bergeaud and Alexandra Krause and Stephane Flibotte and Yoko Shimizu and Hilary J. Anderson and Vincent Mouly and E. E. Jan and Tom A. Pfeifer and James B. Jaquith and Michel Roberge}, booktitle={Nucleic acids research}, year={2016} }