Novel small-molecule inhibitors of RNA polymerase III.

@article{Wu2003NovelSI,
  title={Novel small-molecule inhibitors of RNA polymerase III.},
  author={Liping Wu and Jing Pin Pan and Vala Thoroddsen and Deborah R Wysong and Ronald K. Blackman and Christine Ellen Bulawa and Alexandra E. Gould and Timothy Ocain and Lawrence R Dick and Patrick Errada and Patrick K Dorr and Tanya Parkinson and Tony Wood and Daniel Kornitzer and Ziva Weissman and Ian M Willis and Karen A. McGovern},
  journal={Eukaryotic cell},
  year={2003},
  volume={2 2},
  pages={
          256-64
        }
}
A genetic approach utilizing the yeast Saccharomyces cerevisiae was used to identify the target of antifungal compounds. This analysis led to the identification of small molecule inhibitors of RNA polymerase (Pol) III from Saccharomyces cerevisiae. Three lines of evidence show that UK-118005 inhibits cell growth by targeting RNA Pol III in yeast. First, a dominant mutation in the g domain of Rpo31p, the largest subunit of RNA Pol III, confers resistance to the compound. Second, UK-118005… CONTINUE READING

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