Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.

@article{Bapat2010NovelSI,
  title={Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.},
  author={Aditi Bapat and Lateca S Glass and Meihua Luo and Melissa L Fishel and Eric Long and Millie M Georgiadis and Mark R Kelley},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={334 3},
  pages={988-98}
}
Apurinic/apyrimidinic (AP) endonuclease 1 (Ape1) is an essential DNA repair protein that plays a critical role in repair of AP sites via base excision repair. Ape1 has received attention as a druggable oncotherapeutic target, especially for treating intractable cancers such as glioblastoma. The goal of this study was to identify small-molecule inhibitors of Ape1 AP endonuclease. For this purpose, a fluorescence-based high-throughput assay was used to screen a library of 60,000 small-molecule… CONTINUE READING

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